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A long-acting glucose-dependent insulinotropic polypeptide receptor agonist shows weight loss without nausea or vomiting [abstract]
This has several downstream effects: slower gastric emptying (food stays in the stomach longer, extending fullness), reduced appetite signalling in the hypothalamus, and improved insulin sensitivity, which helps stabilize blood sugar and reduce cravings linked to glucose spikes and crashes
Reflux considerations Gastric Sleeve May worsen reflux in some patients
Whats particularly interesting is the study design: The trial does not put its eggs in one basket Liver disease is the primary endpoint
Below is the weight loss from base weight observed at 3, 6, and 12 months after starting weight loss injectables: Final Takeaway Learning to self-inject can feel overwhelming at firstbut with practice, it becomes second nature
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