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Although a single RCT failed to observe a statistically significant improvement in HOMA-IR (85), this discrepancy is more likely attributable to limited sample sizes, restricted follow-up windows, and heterogeneity in baseline metabolic phenotypes rather than a lack of efficacy

Mithun M et al

Nuclear Signaling : Glutathione levels influence the activation of Nrf2, a transcription factor that upregulates longevity pathways and antioxidant enzyme production, creating a supportive cellular environment against stress

Notably, this method enables sensitive detection of GSH at nanomolar concentrations in human serum, demonstrating strong potential for clinical diagnostic applications [93]