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Notably, Orforglipron (EC 50 1.2 nM), a pyrazolopyridine derivative that acts as a biased partial agonist and is administered orally once daily, has entered Phase III clinical trial (NCT3502970)

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Furthermore, several transcription factors, such as Neurod1, Rfx6, Arx, Foxa1, Foxa2, Pax4, and Pax6 regulate the differentiation of EEC subpopulations [24] (Fig

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325 The Ub chains direct substrates toward autophagic breakdown through the UBA domain of p62, aiding in the elimination of harmful substances during periods of stress

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