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GPX4-independent antioxidative pathways While the system x c GSHGPX4 axis is acknowledged as the main antilipid peroxidation pathway in ferroptosis, recent studies have identified three GPX4-independent mechanisms that also inhibit ferroptosis: ferroptosis suppressor protein 1 (FSP1)/CoQ10, GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4), and dihydroorotate dehydrogenase (DHODH)
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Oxidative stress markers (malondialdehyde, 8-OHdG) potentially tracking antioxidant peptide effects
Lyophilized GHK-Cu powder should be stored at 2 to 8 degrees Celsius away from light and moisture for long-term integrity
