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In fact, Saxenda (liraglutide) has been approved by the FDA for use in weight management in people with a BMI of 30 or higher or a BMI of 27 or higher with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol
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Given that GLP-1 biology is complex and may involve several parallel mechanisms with or without transmembrane receptors (31) and distinct metabolites (32), we chose to next focus on the direct actions of the single metabolite GLP-1(2836) using in-depth in vitro studies into its cellular and molecular actions
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