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This depletion compromises the brains antioxidant defense, leading to increased oxidative damage and neuronal death

The Journal of Clinical Endocrinology & Metabolism, 101(9), 34503458

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A total of 24 subjects with evaluable pharmacokinetic profiles would then result in a probability of at least 80% to obtain a 95% CI for the ratio of fed/fasting groups lying within the range of 0.681.46 times the estimated mean ratio