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Makwana, B., Khadke, S., Kumar, A., Nasir, K., Wadhera, R., Shah, R., Sheth, S., Kong, Y., Navas-Acien, A., Adamkiewicz, G., Rajagopalan, S., Al-Kindi, S., Dani, S

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Iron accumulation is a prevalent characteristic in OA and facilitates ferroptosis-mediated chondrocyte apoptosis

In contrast, persistently stabilized NRF2 in response to KEAP1 or NRF2 mutations causes sustained activation of these genes, leading to the accumulation of xCT/SLC7A11, GCLC, and GCLM that cause a depletion of intracellular glutamate (Sayin et al