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Vomiting, diarrhea, and constipation occur in 20 to 30% of active-drug participants
Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]
The regulation of apoptosis, differentiation, migration, metabolism, survival, and cell proliferation all depend on ROS
Role of p-glycoprotein in glycolipid synthesis
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