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Some estimates suggest an overall 30% loss in brain GSH levels due to normal aging

CCL-11 or Eotaxin-1: an immune marker for ageing and accelerated ageing in neuro-psychiatric disorders

doi:10.3390/pathogens9030231 9

The timepoint chosen (when drug-tolerant cells are emerging after treatment) probably contributes to this effect, and later timepoints (when cells perhaps enter senescence or other more terminally arrested states) are more likely to reflect the expected gene expression patterns