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2003 The landmark 2003 study by Molinoff, Shadiack, Earle, Diamond, and Quon published in Annals of the New York Academy of Sciences confirmed that PT-141 administration to normal men and patients with erectile dysfunction produced a rapid, dose-dependent increase in erectile activity establishing the foundational clinical pharmacodynamic data for PT-141s erectile research application and confirming that the CNS melanocortin pathway generates erectile responses independently of peripheral vascular mechanisms

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Five grams of monohydrate per day is the dose with the strongest evidence [5]