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In the United States, more than 40% of adults have obesity or excess weight, which contributes to higher rates of diabetes, heart disease and high blood pressure
For weight management, NICE has approved specific GLP-1 agonists (Saxenda, Wegovy) under defined criteria
In real-life practice, rebound weight gain is common
Tirzepatide Those who took oral orforglipron after discontinuation of injectable tirzepatide kept off 74.7% of their earlier weight loss at week 52 of the trial
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