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GLP-1 medications are generally prescribed for adults with obesity (BMI 30) or those who are overweight (BMI 27) with related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol

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These findings suggest that liraglutide specifically reduces bone resorption without influencing bone formation.368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption.369,370 Genetic disruption of GLP-1R signaling leads to cortical osteopenia and heightened bone fragility, primarily caused by increased bone resorption by osteoclasts

As suggested by the authors, E