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FIGURE 8 The aforementioned abnormalities at the molecular level (downregulation of the Nrf2/HO-1 axis and GPX4) and subcellular structural level (neuronal somata and mitochondrial impairment) were consistent with the GSH metabolism perturbations identified by multi-omics analyses, collectively reflecting oxidative stress-associated damage in the hippocampus during SAE

effective contraception should be used during treatment Should be discontinued at least 2 months before a planned pregnancy [2] [3] Risk of pancreatitis seek urgent medical attention for severe, persistent abdominal pain Increased risk of gallbladder disease including cholelithiasis and cholecystitis Potential risk of diabetic retinopathy complications in people with type 2 diabetes Risk of hypoglycaemia when used with insulin or sulfonylureas Risk of dehydration leading to acute kidney injury, particularly during initial treatment If you experience side effects, report them through the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk)