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This early redistribution may pose a problem when selenium supplementation is used simultaneously with the thiol chelators, as the primary source of excreted mercury for the thiol chelators is kidney stores of mercury [Citation168, Citation169]

However, the confidence interval for this difference was 5.8 mmHg to 0.1 mmHg, suggesting that the statistical significance of this effect is borderline

The reaction catalyzed by GTP cyclohydrolase 1 (GTPCH) is considered the rate-limiting and committed reaction of BH 4 synthesis

This mismatch between patient expectations and clinical reality can create challenges

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