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In the Brain GLP-1 receptors in the hypothalamus (the region of the brain that controls hunger) are crucial for regulating appetite
The SURMOUNT-1 Phase 3 trial published in The New England Journal of Medicine enrolled 2,539 adults with obesity and demonstrated mean body weight reduction of 20.9% at 72 weeks on tirzepatide 15mg weekly versus 3.1% placebo
The insulin-enhancing effects of GIP and GLP-1 were discovered over 25 years ago, yet new roles for incretin hormones continue to emerge [30]
But things get even more interesting the deeper you dig: Take for example this study (9)
After pregnancy confirmation, liraglutide was discontinued and insulin therapy was started
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