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*Compounded drugs are permitted to be prescribed under federal law but are not FDA-approved and do not undergo FDA review for safety, effectiveness, or quality.

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Adverse Effects Aside from the debated increased risk of DR progression, a separate complication that has garnered widespread attention is the purported association of semaglutide with an increased risk of NAION, a vision-threatening condition

But so is the cost: each generation adds more gastrointestinal side effects, and retatrutide introduced a new signal (dysesthesia) that did not appear in Phase 2