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In a Phase II trial for obesity, once-monthly maridebart cafraglutide achieved impressive weight loss (around 1216% at 52 weeks in people without diabetes, dose-dependent)
Choosing between GLP-1 shots and pills
Supplied as oral capsules for research use
It reduced lines and wrinkles, improved skin density, and increased skin thickness better than both placebo and vitamin K cream
The incretin mimetics, glucagon-like peptide-1 receptor agonists (eg, semaglutide, liraglutide) and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist (ie, tirzepatide), demonstrate the greatest weight loss benefits, with tirzepatide achieving reductions exceeding 20% in some patients
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