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Fractyl's approach specifically minimizes systemic exposure by targeting pancreatic beta cells and using a nutrient-responsive promoter rather than a constitutive one
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This is treatment success transitioning to maintenance phase
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We established a D-galactose-induced aging model in randomly selected male and female mice through intraperitoneal injections of D-galactose (200 mg/kg/day, MCE, HY-N0210), starting at 8 weeks of age for 8 weeks
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