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Specific amino acid substitutions and a C18 fatty-acid side chain enhance albumin binding, reduce renal elimination, and confer resistance to DPP-4 degradation, extending its half-life to approximately one week and enabling once-weekly administration [14]
Second, this was the first study with a longer follow-up period, longer duration of diabetes and large sample size to investigate the association between GLP-1 RAs and DR using real-world clinical data
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A standard insulin syringe has 100 units, which equals 1mL