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Therefore, to achieve EPR-dependent tumor targeting, the optimal size of nanocarriers should be between 50-150 nm [93, 94]

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The mechanism involves gene regulation in chondrocytes (cartilage cells) - Cartalax binds to specific DNA sequences in cartilage tissue, upregulating genes for cartilage matrix proteins (collagen type II, proteoglycans, aggrecan), downregulating inflammatory and degradative enzymes (matrix metalloproteinases), and optimizing the balance between cartilage formation and breakdown

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There may be subnormal levels of vitamin B 6 due to various factors associated with CKD