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Paradoxically, therefore, although less sleep (as in sleep deprivation, for example) is typically associated with decreased daytime alertness in otherwise normal individuals, in the reduced nocturnal sleep of insomnia, studies have observed an increased level of activation and arousal

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Additionally, the depletion of SCFA might result from an overgrowth of D-lactate producing bacteria, which are found at elevated levels in ME/CFS patients and have been studied previously [36]