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Caution and close monitoring are warranted in individuals with preexisting diabetic retinopathy, due to a higher incidence of retinopathy-related complications observed in clinical trials, particularly with semaglutide ( 4 Cardiovascular results 4.1 Evidence of SGLT2 inhibitors in patients with DM2 The management of DM requires a long-term perspective, emphasizing the importance of medication safety over time

1 x Composite major CV events were analyzed in a time-to-first-event analysis with a Cox proportional-hazards model with treatment as a categorical fixed factor and stratified according to SGLT-2i use as baseline

They suspected that the phenomenon might be down to a substance in the gut like 'the hypothetical incretin' (Samols, Marri, Marks 1966

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GHK-Cu contains a chelated copper ion that makes it more oxidation-sensitive than non-metallated peptides like BPC-157