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Both extremes can result in endothelial damage and inflammation
Patients taking oral contraceptives should use non-hormonal or backup contraception for 4 weeks after starting tirzepatide and after each dose increase, as tirzepatide may reduce oral contraceptive effectiveness
The review focuses explicitly on Glucagon-Like Peptide-1 (GLP-1) receptor agonists, newer multi-receptor agonists, and emerging oral small-molecule therapies
Moreover, Genistein, by reduction of pro-inflammatory mediators (IL-6, tumor necrosis factor- (TNF-) and C-reactive protein (CRP)) in serum and intestine in alloxan-induced diabetic rats, reduces the damage of L-cells and leads to an increase in the expression and secretion of GLP-1[191]
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