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This was evidenced by a decreased requirement for intensification of treatment associated with better preservation of glycemic control, as well as better sustained -cell function as reflected in the fasting HOMA-2 during the 2-year follow-up period
a , We constructed a mutant strain that could not synthesize glutathione by knocking out, in the wild-type strain, the GSH1 gene which is essential for glutathione biosynthesis (see Mutant yeasts in the Methods section)
Masmoudi O, Gandolfo P, Tokay T et al (2005) Somatostatin down-regulates the expression and release of endozepines from cultured rat astrocytes via distinct receptor subtypes
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