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These observations are consistent with constraint-based modeling and flux-balance analyses, which indicate that metabolic phenotypes frequently emerge from network-wide redistribution of flux rather than from the activity of individual genes in isolation (Sweetlove and Ratcliffe, 2011

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Upon Sabs phosphorylation by pJNK on the outside of the outer membrane, SHP1 is released into the intermembrane space where it undergoes activation through phosphorylation by a kinase, perhaps by pSrc