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DSIP cortisol modulation may represent a targeted intervention at that upstream root cause one that sits outside the reach of diet, exercise, or conventional metabolic medications

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In controlled studies, glutathione supplementation increased peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) protein levels by 25% and mitochondrial DNA biogenesis by 53% in skeletal muscle, indicating enhanced mitochondrial function supporting exercise capacity

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