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Zubair S, Hafeez S, Mujtaba G

Systemic effects reported or plausibly linked to elevated growth hormone and IGF-1 include water retention, tingling or numbness (paresthesia), joint discomfort, headache, flushing, and transient changes in glucose handling

The Sartorius score is a clinical tool designed to assess the severity of HS

Effect of glutathione infusion on leg arterial circulation, cutaneous microcirculation, and pain-free walking distance in patients with peripheral obstructive arterial disease: a randomized, double-blind, placebo-controlled trial

cited to illustrate range of doses explored in mood disorders and that even lower doses had some effect