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The drug had a half-life of about one week and stronger effects on glycaemia and body weight with mean reductions in HbA 1c of 18 mmol/mol and in body weight of 5.7 kg in the phase-III programme [20]

The investigators hypothesized that treatment with oral GABA, or a combination of GABA/GAD65-alum, would halt or slow the progression of new onset type 1 diabetes (T1DM) by some/all of the following mechanisms: 1) increasing endogenous insulin secretion, 2) suppression of glucagon release, 3) dampening the T-cell mediated autoimmune process

112: 40-46 (1982) Mano J, Miyatake F, Hiraoka E, Tamoi M

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