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Moreover, barrier dysfunction has been linked to diseases originating outside the GI tract, including IgA nephropathy (Tang et al., 2022b), MASLD (Tilg et al., 2022), and multiple sclerosis (Pellegrini et al., 2023)

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Such a redox environment may provide a basis for ROS-dependent signaling pathways to subsequently drive progressive phenotypes such as proliferation, survival, and angiogenesis ( Figure 2 Within the tumor microenvironment, hormonal signaling serves as a critical upstream trigger that drives HGSOC progression through ROS-dependent pathways