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18 The trial found that expectant management was noninferior to early ibuprofen treatment for the composite outcome, mainly driven by a lower incidence of moderate-to-severe BPD in the expectant management group (absolute risk difference -17.6, 95% confidence interval (CI) 30.2 to 5.0)

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Doxorubicin generates oxidative stress, damages mitochondria in heart cells, and triggers apoptosis (programmed cell death)