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Madison AA, Belury MA, Andridge R, Renna ME, Rosie Shrout M, Malarkey WB, et al

PMID: 2 AmaralE

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Interestingly, the identification of ESR1 as a inhibited transcription factor by IPA and a major hub gene in network analysis, indicates an important role of ESR1 modulation in hyperplastic ovarian stroma

Studies demonstrate FOXO4-DRI achieves comparable renal function restoration to genetic clearance of senescent cells using the p16-3MR suicide gene system, confirming that therapeutic effects result specifically from senescent cell elimination rather than off-target actions