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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown

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Funnel plot asymmetry and Eggers tests suggested potential small-study effects in some datasets (HDRS, BDI), raising concerns about publication bias

doi:10.3390/nu10030349 Salehpour S, Nazari L, Hoseini S, Moghaddam PB, Gachkar L