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A powerful secretagogue, it has long been known that l-arginine promotes the secretion of insulin and glucagon from the - and -cells of the pancreas, respectively, which may be partly due to its potent action at the GPRC6a receptor (162164)

PMID 15649736

Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency

In my opinion, this is a miserable return on investment given the billions invested and decades spent chasing tails on the wrong hypotheses