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doi: 10.1002/jimd.12127 3 MikkelsenKApostolopoulosV

Integrated human cardiac metabolism studies reinforce that the failing heart cannot be understood without considering substrate delivery, oxygen use, organ crosstalk, and patient phenotype (13, 31)

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Similar to the statin lipid-lowering drugs mentioned earlier, other lipid-lowering drugs, such as probucol, also exhibit the capability to restore the inhibited GSH system and defend the myocardium from oxidative damage after exposure to pathological factors, for example, ISO and cyclophosphamide [242, 243]