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PubMed, Embase, Cochrane CENTRAL, and ClinicalTrials.gov were searched through for randomized trials with 24 weeks of follow-up in patients with T2DM and CKD
The two most prevalent side effects are nausea and constipation
It also has limited utility in advanced beta-cell failure (where insulin secretion declines)
Vako, L
This means some side effects, like back pain, may not happen right away
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