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1 The study authors wrote that this pattern is "consistent with a potential direct skeletal effect of GLP-1 RA therapy" and pointed to preclinical evidence suggesting GLP-1s may promote osteogenic differentiation, inhibit osteoclasts, and signal directly through receptors on bone-forming cells

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Mtb infection of macrophages resulted in decreased levels of GSH and GPX4, increased free iron, mitochondrial superoxide, and lipid peroxidation