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Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate
iFSP1 also inhibits the Gpx4-knockout cell growth as a dose-dependent manner but does not inhibit the wild type cell growth
Once inside cells, glutathione binds to free radicals, heavy metals, and toxins, converting them into harmless compounds that are eliminated by the liver and kidneys
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