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Some people splitting into 2x/week report fewer GI sides, but it's not required

A few things drive that difference: how deep the deficiency runs, your metabolism and body composition, whether the root cause is dietary or an absorption problem, and any underlying condition thyroid disease, autoimmune disorders, chronic GI disease that can mask or delay how quickly you notice a difference

Date, concentration, total volume

Serious vitamin B-12 deficiency may result in anemia, stomach problems, and nerve damage