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Few of the vaccines described above have been tested in challenge models against viruses other than SARS-CoV-2 or have had the breadth of cross-reactive immunity they elicit rigorously tested against the full spectrum of coronaviruses

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Studies have examined its activity in musculoskeletal tissue models including tendon, ligament, and bone repair research, as well as gastrointestinal cytoprotection and neurological models

The exact frequency depends on factors like body weight, treatment goals, and medical advice