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Song NN, et al
Food reduces oral semaglutide bioavailability by approximately 60%, making adherence to fasting requirements essential for therapeutic effectiveness
This pattern suggests Canadian approval for Retatrutide could occur around 2028-2029 if the US approval timeline holds at 2026-2027
This includes those who: Have heart disease, kidney problems, or overweight Want to avoid weight gain or low blood sugar from other diabetes medicines People with overweight or obesity, including: Adults with a body mass index (BMI) of 30 or higher Adults with a BMI of 27 or higher and at least one weight-related health problem (such as high blood pressure or sleep apnea) Adults who have not met weight-loss goals with lifestyle changes alone Adolescents with obesity who qualify for certain GLP-1 medications Who should not receive GLP-1 medications
