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They are also not approved by the FDA (Food and Drug Administration) for muscle enhancement

Inefficiency of the phagocytosis process leads to the formation of residual lipid-protein granules that cannot be degraded, known as lipofuscin, and generation of ROS occurs from the constant exposure of lipofuscin to light and oxygen tension 1

This isn't just aesthetic

There also appears to be an increased risk for mercury overload when progressing through the menopause or those that suffer with osteopenia or osteoporosis

Intracellular ROS homeostasis ROS are a class of oxygen-containing and highly reactive substances, generated within cells from both endogenous and exogenous sources [36]