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Febuxostat: updated advice for the treatment of patients with a history of major cardiovascular disease

If signs of severe allergic reaction occur (difficulty breathing, facial/tongue swelling, severe rash), call 911 immediately

Plaintiffs argue that had they been informed of the risks, they might have made different decisions regarding their treatment options

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No sample size calculation was performed for any study, however, for all studies, we typically start with an n = 10, which is usually sufficient to see statistically different changes between the groups, as well as a sufficient sample size for subsequent analyses on tissues and serum