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doi: 10.1002/oby.24239 14 JingMShenglianGShijunGQuanZFangYHaifengZet al
Inflammation haptocorrin levels can increase due to granulocyte activation or as an acute phase response Decreased clearance: Renal failure decreased clearance of transcobalaminB12 complexes Mechanism: Most elevated B12 is not free or biologically active , but rather bound to haptocorrin , which has a long half-life and is increased in certain diseases
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