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For Semaglutide and Tirzepatide, this happens around weeks 18-22
ONeill, L
In the early weeks, you might see some dryness or mild flaking, thats a sign the skin is adjusting
Haidari F, Mohammadshahi M, Zarei M, Haghighizadeh MH, Mirzaee F
Another study looked at DSIP-related hormone signaling patterns in patients with major depressive disorder, but it did not test whether DSIP improved anxiety, stress, mood, or cortisol regulation as a treatment [9]
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