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DSIP was discovered decades ago and initially attracted substantial scientific interest, yet large contemporary clinical programs did not emerge

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the downregulation of many IR-associated genes in the AT of subjects with PWS, including those encoding proinflammatory markers (176)

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Exendin-4 increases absence-like seizures and anxietydepression-like behaviors in WAG/Rij rats

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They are not reviewed or approved by the FDA for safety or effectiveness and may be prescribed when FDA-approved alternatives are unavailable or unsuitable

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