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Lipofuscin generates a large amount of ROS under blue light irradiation, which triggers endoplasmic reticulum stress (ER stress) in RPE cells, manifested by upregulation of GRP 78 and CHOP protein expression, and then induces cell apoptosis through activation of Caspase-3 and decreased expression of Bcl-2 (Zhao, 2015)

Design of prodrugs with reactive oxygen species as activators and their application in tumor therapy

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