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Testosterone levels are affected by luteinizing hormone (LH, a pituitary hormone that regulates testicular production of testosterone) and sex hormone-binding globulin (SHBG, a protein that binds testosterone, rendering it inactive), as well as levels and activity of dehydroepiandrosterone (DHEA, a hormone precursor to testosterone and estrogen) and aromatase (an enzyme that converts testosterone to estrogen)
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Chronic conditions like long-standing GERD may benefit from extended 8 to 12 week protocols
Molecular mechanisms and potential clinical significance of S-glutathionylation
This hormonal cascade works as follows: The hypothalamus releases gonadotropin-releasing hormone (GnRH) GnRH signals the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) LH stimulates the Leydig cells to produce testosterone Rising testosterone feeds back to the hypothalamus and pituitary to regulate production (negative feedback loop) Testosterone is responsible for: Muscle protein synthesis and lean body mass maintenance Bone mineral density Red blood cell production Libido and sexual function Energy, mood, and cognitive function Fat distribution and metabolic health Normal total testosterone in adult men ranges from approximately 300 to 1,000 ng/dL, with levels declining by roughly 1 to 2 percent per year after age 30 (Harman et al., 2001)
