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Their involvement in cancer cell growth and differentiation, and in the development of resistance to anticancer agents, has made them attractive drug targets
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The sophisticated process of mitochondrial biogenesis requires coordination between mtDNA and nDNA, including mtDNA transcription and translation, translation of nDNA-encoded transcripts, membrane recruitment, protein import, and assembly of the OXPHOS complexes (Wu et al., 1999), and PPARG coactivator 1 beta (PGC1) along with PPARG related-coactivator 1 (PRC) were discovered subsequently (Patel et al., 2012
Enlarged pores
Bioavailability is higher, though the rapid peptidase degradation still limits systemic peptide exposure
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