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Supplementation with pycnogenol in early stages of varicose veins may slow progression to chronic venous insufficiency (Belcaro 2014)
No changes were observed in the normoinsulinemic group, whose AUC HIE did not change during the 24 weeks of treatment
In addition, aberrant Ca 2+ signaling causing mitochondrial dysfunction can adversely affect neurotransmitter signaling and lead to excitation/inhibition imbalance [94, 97, 98]
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Modulates several inflammatory pathways that would otherwise slow tissue repair
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