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Run the math and you get late 2026 as the absolute floor, with 2027 being the most likely approval year for at least the obesity indication

ATTAIN-1 trial results for orforglipron, a once-daily oral GLP-1RA, show up to 12.4% weight loss at 72 weeks

Mahadevappa R, Ma R, Kwok HF

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This is what leads to the build of toxins, like lactic acid, that lead to soreness